Thies Gehrmann
Bioinformatics - Sequence analysis - Fungal biology

 

I am a postdoctoral bioinformatician at the Molecular Epidemiology department of the Leiden University Medical Center, embedded in the Leiden Computational Biology Center.

Together with the Max-Plank institute for biology of ageing, I will conduct research on the effect of medication and lifestyle interventions on gene regulation to identify or elucidate the impact of genes related to healthy ageing.

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Research Highlights

Homokaryon specific expression

Nuclear-specific expression

Schizophyllum commune has an extensive and functional alternative splicing repertoire

Fungal alternative splicing

Proteny: discovering and visualizing statistically significant syntenic clusters at the proteome level

Discovering distant synteny

Recent Projects

Greedy gene matching for large scale homology detection

Greedy Gene Matching

Homokaryon specific expression

Nuclear-specific expression

Schizophyllum commune has an extensive and functional alternative splicing repertoire

Fungal alternative splicing

DT-cut: Dynamic tree cut

Dynamic Tree cut

The transcriptional regulator c2h2 accelerates mushroom formation in Agaricus bisporus

c2h2 in A. bisporus

Mutations accumulate in an experimental design

SNPs in experimental design